A placebo-controlled study of pregnant women compared application of a cream containing a CAE, vitamin E alpha tocopherol , and collagen-elastin hydrolysates to placebo[ 70 ]. Centella asiatica Indian pennywort , an effective therapeutic but a weak sensitizer. University Park Press Crossref. Orally consuming an excessive amount of CA i. CA was described to possess CNS effects in Indian literature such as stimulatory-nervine tonic, rejuvenant, sedative, tranquilizer and intelligence promoting property[ 27 ].
Effects of Centella asiatica extract on dermal wound healing in rats. Indian J Pharm Sci. The effects of CA upon pain antinociception and inflammation in rodent models were reported[ 49 ]. Antimycotic activity of CA was also reported[ 57 ]. Monographs for herbal medicinal products. Animal studies showed that CA extracts inhibited gastric ulceration induced by cold and restraint stress, in rats.
The contents of monoamine neurotransmitters and their metabolites in rats cortex, hippocampus centepla thalamus were evaluated wherein significant reduction of the corticosterone level and increase of the contents of 5-HT, NE, DA and their metabolites 5-HIAA, MHPG in rat brain were observed which further strengthened the postulated thessi of total triterpenes of CA in ameliorating the function of HPA axis and increasing the contents of monoamine neurotransmitters for its antidepressant effects.
CATF proved to be effective on microcirculation and capillary permeability.
One recent study described protective effect of CA extracts against colchicine induced cognitive impairment and associated oxidative damage in rats[ 83 ]. The cognitive impairment was associated with free radical generation in the asaitica in the above study.
PHYTOCHEMICAL ANALYSIS OF CENTELLA ASIATICA L. LEAF EXTRACTS.
In the treatment of scleroderma, it might also assist in stabilizing connective tissue growth, reducing its formation as it reportedly stimulated the formation of hyaluronidase and chondroitin sulfate, as well as exerted a balancing effect on the connective tissue[ 25 ]. The plant extracts were also tested for its radioprotective properties at a sublethal dose 8 Gy of Co 60 gamma radiation[ 52 cdntella.
Crude extract containing glycosides isothankuniside and thankuniside showed antifertility action in mice[ 1415 ]. Apart from wound healing, the herb is recommended for the treatment of various skin conditions such as leprosy, lupus, varicose ulcers, eczema, psoriasis, diarrhoea, fever, amenorrhea, diseases of the female genitourinary tract and also for relieving anxiety and improving cognition. CA has also been investigated to demonstrate its role in periodontal therapy[ 48 ].
Triterpenoid, saponins, the primary constituents of Centella asiatica are manly believed to be responsible for its wide therapeutic actions. People taking the herb for an extended period of time up to 6 asiatiac should take a 2-week break before taking the herb again.
This article has been cited by other articles in PMC. Stimulation of collagen synthesis in fibroblast cultures by a triterpene extracted from Centella asiatica. Effect of Centella asiatica on cognition and oxidative stress in an intracerebroventricular streptozotocin model of Alzheimer’s disease in rats.
Singh P, Singh JS. A plant with immunse medical potential and threatened. Anthelmintic activity of Platycladus orientalis leaves extract. Centella asiatica improves physical performance and health related quality of life in healthy elderly volunteers. Moreover, more double blind randomized clinical trials are needed for investigating its sedative, analgesic, antidepressive, antiviral and immunomodulatory effects that have been demonstrated experimentally in animals.
The effects of CA upon pain antinociception and inflammation in rodent models were reported[ 49 ]. Asiaticoside, a constituent in CA, has been reported to possess wound healing activity by increasing collagen formation and angiogenesis[ 1920 ]. In the nineteenth century, CA and its extracts were incorporated into the Indian pharmacopoeia, wherein in addition to wound healing, it was recommended for the treatment of various skin conditions such as leprosy, lupus, varicose ulcers, eczema, psoriasis, diarrhoea, fever, amenorrhea, and diseases of the female genitourinary tract[ 8 ].
The herb is also used by the people of Java and other Indonesian islands. The lower number of circulating endothelial cells was attributed to the protective effect of CATF on vascular intima integrity[ 62 ].
Total triterpenic fraction of Centella asiatica in chronic venous insufficiency and in high-perfusion microangiopathy. In vitro anthelmintic activity of Murraya koenigii Leaves extracts. Despite large number of studies reported over the past decades on the evaluation of biologically active components and their mechanisms of action, the outcome of these studies is still unsatisfactory.
For example, in one study, patients with post phlebetic syndrome PPS showed a greater number of circulating endothelial cells compared to the normal subjects[ 62 ].
Pharmacological Review on Centella asiatica: A Potential Herbal Cure-all
Yet, another study was conducted to evaluate the possible anti-ulcerogenic activity of fresh juice of CA against ethanol- aspirin- cold-restraint stress- and pyloric ligation induced gastric ulcers in rats. The standardized CA extracts and asiaticoside were well tolerated in experimental animals especially by oral route. This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3. Radioprotection of Swiss albino mouse by Centella asiatica extract.
Centella asiatica L Phytochemical Analysis Leaf extracts. Conference SeriesVolumeBiology.
Handbook of Medicinal Herbs. The extract increased cellular proliferation and collagen synthesis at the wound site, as evidenced by increase in DNA, protein and collagen content of granulation tissues.